When it comes to making headlines, Elon Musk is no stranger to shaking things up — whether it’s in the world of tech, entertainment, or even personal health. Recently, the billionaire innovator shared a personal update that caught a lot of attention: his switch from using the popular diabetes drug Ozempic to Mounjaro for weight management.

So, why did the world’s favorite tech mogul make the switch? Let’s dive in.

Ozempic vs. Mounjaro: What’s the Difference?

Originally designed to treat Type-2 diabetes, Ozempic has also gained massive popularity as a weight-loss aid — especially among celebrities and influencers. Its active ingredient, semaglutide, helps regulate blood sugar levels and curb appetite.

Meanwhile, Mounjaro — featuring the active ingredient tirzepatide — goes a step further. Approved specifically for weight loss in the UK, Mounjaro not only regulates blood sugar but also significantly reduces appetite, helping users feel fuller for longer.

In short: while both medications offer benefits for managing weight, Mounjaro is purpose-built for it — and that distinction made all the difference for Musk.

Elon Musk’s Experience: A Shift for the Better

Last December, Elon Musk humorously revealed that he’d made the switch from Ozempic to Mounjaro, while sharing a festive photo of himself dressed as Santa.

“Ozempic Santa,” Musk joked. “Technically, Mounjaro, but that doesn’t have the same ring to it.”

Beyond the humor, Musk had a serious reason for the change. He candidly explained that Ozempic came with some pretty unpleasant side effects for him — saying it made him “fart and burp like Barney from The Simpsons.” Ouch.

Looking for a better option, Musk tried Mounjaro and quickly noticed the difference. “Mounjaro seems to have fewer side effects and be more effective,” he wrote on X (formerly Twitter).

In typical Musk fashion, he wasn’t shy about letting the world know exactly what worked best for him.

Musk Isn’t Alone

Interestingly, Elon isn’t the only public figure who prefers Mounjaro over Ozempic.

TV personality Jeremy Clarkson shared that he initially tried Ozempic but struggled with severe nausea. “My body lost the ability to deal with gluttony,” Clarkson admitted in his Times column. Although he lost weight, he described it as a miserable experience filled with frequent sickness.

Clarkson eventually made the switch to Mounjaro — and while he joked about surviving on “a handful of sunflower seeds,” he found it a more manageable and effective option overall.

Comedian Amy Schumer echoed similar sentiments. She revealed that Ozempic left her “bedridden” and “vomiting,” whereas Mounjaro gave her better results with fewer side effects. Plus, with the added support from hormonal treatments for perimenopause, Schumer said she was finally feeling great.

Why It Matters

Elon Musk’s openness about his health journey shines a light on an important topic: not every medication works the same for everyone. In a world where entertainment news often glamorizes celebrity transformations, it’s refreshing to see someone like Musk being honest about the ups and downs of weight management.

And with Mounjaro gaining popularity for its more targeted approach to weight loss — especially among high-profile figures — it’s clear that this medication might just be the next big thing in both healthcare and celebrity culture.

At the end of the day, whether you’re launching rockets, hosting SNL, or simply trying to live a healthier life, finding what works best for you is what truly matters. And if Elon Musk’s experience tells us anything, it’s that sometimes, the switch is worth it.