David Raya, keeper (£6m), William Saliba (£6.1m) and Gabriel (£7.2m) – Fulham (h)

If Arsenal win the Premier League title, their defence will have to finish the season well, so backing their defensive assets – a good tactic this season – is the way forward.

Double Arsenal defence paid off last week and Fulham are low scorers on the road (less than a goal per game on average).

Going for a triple-up this week does not even feel like a gamble.

James Hill, Bournemouth, £4.2m – Crystal Palace (h)

It is a toss-up between Hill and centre-back partner Marco Senesi, so the cheaper player get the nod for budget reasons.

There is a high chance of defensive contribution points (defcon) and Palace will be coming off a European semi-final trip to Poland. It is likely that key attacking players will be rested.

Nico O’Reilly, Manchester City, £5.1m – Everton (a)

With City back in action this week, it is time to go return to O’Reilly, who is an incredible vein of form.

The highest-scoring defender in the past 10 gameweeks – and he has missed two matches – with five attacking returns and four clean sheets in eight games.

He will likely be playing out of position in midfield, which in theory makes him even more of an attacking threat.

James Justin, Leeds United, £3.9m – Burnley (h)

Leeds are almost certainly safe with one more win – if not already – and relegated Burnley at home is their best chance.

Daniel Farke’s side kept a clean sheet in a solid home win over Wolves in their previous home game, where Justin had a 16-point haul.

While you cannot rely on that return, he has more shots per 90 minutes than any other Leeds defender this season, while playing left centre-back gives him more chance of defcon.