“Best Medicine” is resonating with audiences across the board. The Josh Charles-led Fox medical dramedy delivered the network’s most-watched fall entertainment episode in almost four years with its Season 2 premiere on Sept. 20, reaching 11 million total viewers across platforms to date, TheWrap can reveal exclusively.

The milestone surpasses an episode of hit series “9-1-1” that aired in November 2022, months before the first responder drama was canceled at Fox and moved to ABC.

For “Best Medicine,” the Season 2 premiere marked the show’s most-watched episode to date among the adults 18-49 demographic, per Fox data. Non-linear viewership was measured through Oct.3.

The momentum carried into Episode 2, which debuted Sept. 29 in its regular Tuesday at 8 p.m. timeslot and scoring the show’s highest-rated and most-watched episode at that time so far. The hour also became Fox’s most-watched drama episode in more than three-years, excluding post-NFL programming.

The show is also finding new viewers on Netflix, with Season 1 generating 1.63 billion viewing minutes from Aug. 4 to Sept. 27, per Fox data. “Best Medicine” tied No. 1 in average audience among acquired titled and No. 5 in total minutes watched.

Across linear and non-linear platforms (the show streams on Hulu as it rolls out new episodes), “Best Medicine” Season 1 has reached 23.8 million total viewers across platforms, including repeats. That season is also averaging 12.9 million multiplatform viewers.

“Best Medicine,” an American remake of the British series “Doc Martin,” stars Charles, Abigail Spencer, Josh Segarra, Cree Cicchino, Annie Potts, Stephen Spinella and Jason Veasey. Ben Silverman, Rodney Ferrell, Howard T. Owens, Liz Tuccillo, Mark Crowdy, Philippa Braithwaite, Jay Karas and Tyson Bidner serve as executive producers. Jamie Babbit served as an executive producer on the series’ first two episodes, which he also directed.

The show is produced by Fox Entertainment Studios and is distributed by Fox Entertainment Global.

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Jessica Chastain cried on command and showed off her sinister “Other Mommy” smile on “Jimmy Kimmel Live!,” earning praise from the internet Thursday.

The Academy Award-winning actress taught the late-night host and his audience how she crafted the creepy smile for her upcoming horror film. She shared that the trick was to hold tension in her body while plastering on a fake smile.

Chastain shook slightly as she locked into the expression, dropping a single tear as she stared down the camera lens.

“You just spurted out that tear with no problem like that?” the late night host asked.

“I’m a trained actress, Jimmy,” she replied.

Users online praised the actress for her technical skill, slightly shading her counterparts that have to “go method to play the most basic male characters.”

“None of that method acting BS,” another X user commented.

Others online were impressed that the actress shared the technique behind her expression.

“I love her. I always cringe when most actors can’t muster a tear, so they have to hide their face to cry,” another said.

Chastain trained at the American Academy of Dramatic Arts before attending Juilliard to study drama. She has received numerous awards for her acting, including an Academy Award for “The Eyes of Tammy Faye” and a Golden Globe Award for “Zero Dark Thirty.”

In her upcoming film “Other Mommy,” she plays a mother who tries to protect her children from a supernatural entity that resembles her exactly. The horror film premieres in theaters Friday.

Keep reading for more reactions to Chastain’s crying on command.

I love her. I always cringe when most actors can’t muster a tear so they have to hide their face to “cry.”

— Cristian Paez Jr (@iamchrispjr) October 8, 2026

Jessica Chastain casually showing how she created that nightmare-inducing smile for OTHER MOMMY is somehow creepier than the actual scene.

The fact that there’s a real technique behind that expression makes it even more unsettling. https://t.co/wfAiVMBljw

— Jan (@jayJan011) October 8, 2026

no need for method acting and stuff like that. the best actors know that, yes, acting is emotions but it’s also technical

— krub (@nats_ken) October 8, 2026